研究领域：

研究领域包括：细胞力学生物学、生物软材料力学与制造、柔性结构力学-设计-制造等。作为项目负责人，主持国家自然科学基金面上项目、深圳市重点项目、深圳市面上项目及多项龙头企业横向课题；曾主持美国国家科学基金项目以及美国机械工程师学会Haythornthwaite Research Initiation Grant Award。课题研究内容涵盖细胞力-生-化耦合模型、柔性结构计算力学、心肌器官芯片中的细胞生物力学与多功能结构设计、柔性折叠屏力学、生物打印等方向。更多信息请访问【力生物学与工程实验室】网站：https://yuan.mae.sustech.edu.cn/

工作经历：

◆ 2019 至今，南方科技大学 力学与航空航天工程系 长聘副教授 正研究员
◆ 2014 – 2019， 罗德岛大学 机械与工业系统工程系  Tenure-Track助理教授
◆ 2012 – 2014， 哈佛大学 工程与应用科学院 Disease Biophysics Group博士后
◆ 2011 – 2012， 布朗大学 工学院 博士后

学习经历：

◆ 2007 – 2010，宾州州立大学 工程科学与力学 博士

◆ 2005 – 2007，阿拉斯加大学 机械工程 硕士

◆ 1998 – 2002，清华大学 工程力学系 本科

代表性发明专利：

◆ 心肌器官芯片多功能结构专利 (2项)

◆ 无痛结肠镜柔性机械套管专利 (2项)

论文发表：

（了解我们最新的论文成果，请访问实验室主页）

[J68] Jiashen Guan, Xin Li, Hongyan Yuan, and Ju Liu. 2026. “Hyperelastic Modeling Based on Generalized Landau Invariants and Multi-Stage Calibration.” Journal of the Mechanics and Physics of Solids 206: 106338.

[J67] Abuzar Es’haghi Oskui, Jinrui Cao, Sorour Sadeghzade, and Hongyan Yuan*. 2025. “Influence of Loading Mode on the Prediction Accuracy of Nonlinear Viscoelastic Models for Soft Adhesives.” International Journal of Solids and Structures 322: 113595.

[J66] Jingyi Liu, WenKai Yu, Dingcong Zhang, Yuanbin Liu, Xin Li, Abuzar Eshaghi Oskui, Wenjun Xu*, and Hongyan Yuan*. “Novel structural flexible magnetic tactile sensors: Design, numerical studies and tactile recognition” IEEE Robotics and Automation Letters (RA-L), 2025, accepted.

[J65] Jiayi Hu, Zhi Gong, Yuanlong Li, Peng Dong, and Hongyan Yuan*. “Design and Optimization of a Mechanical Metamaterial Featuring Dual Tunability in Auxeticity and Bandgap Modulation.” Composite Structures 360 (April 2025): 119050.

[J64] Huiru Wang, Qingbo Lai, Dingcong Zhang, Xin Li, Jiayi Hu, Hongyan Yuan*. “A systematic study on DLP printing of 0-3 ceramic composites for piezoelectric metastructures”, Research 8 (January 2025): 0595.

[J63] Tiankai Zhao, Hongyan Yuan, and Xiongfei Zheng. “Thermodynamic Model of Epithelial-Substrate Coupling in Monolayers: Effects on Traction Forces and Colony Size.” Physica A: Statistical Mechanics and Its Applications, December 2024, 130336.  

[J62] Xin Li, Dingcong Zhang, Huiru Wang, Rui Yang, and Hongyan Yuan*. “Shape-Programmable Hard-Magnetic Soft Actuators with High Magnetic Particle Content via Digital Light Processing Method.” Composites Part A: Applied Science and Manufacturing 188 (January 1, 2025): 108554.

[J61] Yuenan Wang, Fada Guan, Fukun Ouyang, Hongyan Yuan, Ming Su, and Xuanfeng Ding. “Heart Ultrasound and Biomechanical Evaluation of Radiation‐induced Heart Toxicity Using Transthoracic Echocardiogram (TTE) and Dynamic Mechanical Analysis (DMA).” Precision Radiation Oncology, November 12, 2024

[J60] Xin Li, Dingcong Zhang, Jiashen Guan, Ju Liu, and Hongyan Yuan*. “Magneto-Viscoelastic Rod Model for Hard-Magnetic Soft Rods under 3D Large Deformation: Theory and Numerical Implementation.” International Journal of Solids and Structures, October 5, 2024, 113101.

[J59] Yuechao Dong, Hongyan Yuan, Guixing Ma, and Huiling Cao. “Bone-Muscle Crosstalk under Physiological and Pathological Conditions.” Cellular and Molecular Life Sciences 81, no. 1 (December 2024): 310.

[J58] Xin Li, Wenkai Yu, Xiaoyan Zhu, Ju Liu, Hongyan Yuan*, “Geometrically exact 3D arbitrarily curved rod theory for dynamic analysis: application to predicting the motion of hard-magnetic soft robotic arm”, Applied Mathematical Modelling, 134 (October 1, 2024): 71–96.

[J57] Jinrui Cao, Abuzar Es'haghioskui, Sorour Sadeghzade, Yuanlong Li, Zhaoyan Huang, Xin Li, Peng Dong, Jiayi Hu, Runsheng Hou, Hongyan Yuan*, “Large Strain Mechanical Behaviors of Optically Clear Adhesives for Flexible Electronic Devices under Different Temperature, Humidity, and Strain Rates”, Journal of Applied Polymer Science, June 11, 2024, e55868.

[J56] Jiayi Hu, Peng Dong, Jinrui Cao, Zhi Gong, Runsheng Hou, and Hongyan Yuan*. “Dynamic Bandgap Responsiveness of Modified Re-Entrant Metamaterials in Thermal-Mechanical Field.” Journal of Materials Research and Technology 30 (May 1, 2024): 7328–39.

[J55] Sorour Sadeghzade, Jinrui Cao, Rui Yang, Yuanlong Li, Yanping Li, Dingcong Zhang, Jingyi Liu, Ziyue Yu, Liang Fang, and Hongyan Yuan*. “Highly Stretchable Alginate/Methylcellulose Hydrogels for 3D Bio-Printing: Photopolymerization Approach Enhancing Structural Integrity.” Giant, May 7, 2024, 100280.

[J54] Jinrui Cao, Abuzar Es’haghioskui, Peng Dong, Zhi Gong, and Hongyan Yuan*. “Mechanical Simulation and Debonding Risk Analysis of OLED Panels with Optically Clear Adhesives.” Displays, April 19, 2024, 102722.  

[J53] Wenkai Yu, Jingyi Liu, Xin Li, Ziyue Yu, Hongyan Yuan*. “A Novel Hybrid Variable Stiffness Mechanism: Synergistic Integration of Layer Jamming and Shape Memory Polymer.” IEEE Robotics and Automation Letters, 2024, 1–8.

[J52] Chengyao Zhang, Yaxin Fang, Chao Shi, Hongyan Yuan, and Xin Yi. “Stretching Transition of Vesicles with Confined Filament Loops: Morphological Evolution with Filament Distortion and Reorientation.” Giant, December 27, 2023, 100233.

[J51] Runsheng Hou, Peng Dong, Jiayi Hu, Zhi Gong, Sorour Sadeghzade, Jinrui Cao, and Hongyan Yuan*. “An Optimized Lozenge-Chiral Auxetic Metamaterial with Tunable Auxeticity and Stiffness.” Materials & Design 237 (January 2024): 112530.

[J50] Jiayi Hu, Peng Dong, Runsheng Hou, Jinrui Cao, Sorour Sadeghzade, and Hongyan Yuan*. “Functionally Graded IWP Reinforced Cementitious Composites: Design, Fabrication, and the Enhanced Ductility.” Thin-Walled Structures 192 (November 1, 2023): 111199.

[J49] Moran Yadid, Mario Hagel, Megan Beldjilali Labro, Baptiste Le Roi, Carina Flaxer, Eli Flaxer, A. Ronny Barnea, Shai Tejman-Yarden, Eric Silberman, Xin Li, Rossana Rauti, Yael Leichtmann-Bardoogo, Hongyan Yuan, Ben M. Maoz “A Platform for Assessing Cellular Contractile Function Based on Magnetic Manipulation of Magnetoresponsive Hydrogel Films.” Advanced Science n/a, no. n/a (n.d.): 2207498.

[J48] Sorour Sadeghzade, Jinrui Cao, Dingcong Zhang, Peng Dong, Jiayi Hu, Abuzar Es’haghioskui, and Hongyan Yuan*. “Soft Acrylate Monomer-Based Optically Clear Adhesive for Foldable Electronics: Mechanical Characterization and Fractography Analysis under Large Strain. European Polymer Journal 197 (October 10, 2023): 112337. ”   

[J47] Guan, Jiashen, Hongyan Yuan, and Ju Liu. “A Structure-Preserving Integrator for Incompressible Finite Elastodynamics Based on a Grad-Div Stabilized Mixed Formulation with Particular Emphasis on Stretch-Based Material Models.” Computer Methods in Applied Mechanics and Engineering 414 (September 1, 2023): 116145. https://doi.org/10.1016/j.cma.2023.116145.

[J46] Li, Xin, Wenkai Yu, Jingyi Liu, Xiaoyan Zhu, Huiru Wang, Xiaoyu Sun, Ju Liu, and Hongyan Yuan*. “A Mechanics Model of Hard-Magnetic Soft Rod with Deformable Cross-Section under Three-Dimensional Large Deformation. International Journal of Solids and Structures 279 (September 2023): 112344. ”

[J45] Dan Wu, Gengxin Du, Haochen Liu, Wei Chen, Xin Li, Zhibei Wang, Haodong Tang, Bingyang Liu, Chenxi Liu, Yulong Chen, Zhulu Song, Weiwei Deng, Hongyan Yuan*, Kai Wang*, Xinyan Zhao*, “Flexible Microcomb Printed PbS Quantum Dot Film Enables Scalable Fabrication of Near Infrared Photodetector.” Advanced Optical Materials n/a, no. n/a (2023): 2300945.

[J44] Zhao, Tiankai, and Hongyan Yuan. “The Analytical Solution to the Migration of an Epithelial Monolayer with a Circular Spreading Front and Its Implications in the Gap Closure Process.” Biomechanics and Modeling in Mechanobiology, May 7, 2023.

[J43] Megan L. Rexius-Hall, Natalie N. Khalil, Sean S. Escopete, Xin Li, Jiayi Hu, Hongyan Yuan, Sarah J. Parker, and Megan L. McCain. “A Myocardial Infarct Border-Zone-on-a-Chip Demonstrates Distinct Regulation of Cardiac Tissue Function by an Oxygen Gradient.” Science Advances 8, no. 49 (December 7, 2022)

[J42] Huiru Wang, Jingyi Liu, Sorour Sadeghzade, Runsheng Hou, and Hongyan Yuan*. “Improved Corona Discharge-Based Modified Poling Method for 0–3 PZT/PEGDA Piezoelectric Composites.” Ceramics International, December 2, 2022.     

[J41] Sorour Sadeghzade, Jingyi Liu, Huiru Wang, Xin Li, Jinrui Cao, Huiling Cao, Bin Tang, and Hongyan Yuan*. “Recent Advances on Bioactive Baghdadite Ceramic for Bone Tissue Engineering Applications: 20 Years of Research and Innovation (a Review).” Materials Today Bio 17 (December 2022): 100473.

[J40] Tiankai Zhao, and Hongyan Yuan. “A Full Contraction-Reaction-Diffusion Model for Pattern Formation in Geometrically Confined Microtissues.” Applied Mathematical Modelling, October 2022, S0307904X22005212.

[J39] Xin Li, Wenkai Yu, Mehdi Baghaee, Changyong Cao, Dunyu Chen, Ju Liu, and Hongyan Yuan*. “Geometrically Exact Finite Element Formulation for Tendon-Driven Continuum Robots.” Acta Mechanica Solida Sinica, February 16, 2022.  

[J38] Yuenan Wang, Ye Li, Zonghai Sheng, Weiwei Deng, Hongyan Yuan, Shubin Wang, and Yajie Liu. “Advances of Patient-Derived Organoids in Personalized Radiotherapy.” Frontiers in Oncology 12 (2022).

[J37] Wenkai Yu, Xin Li, Dunyu Chen, Jingyi Liu, Jiaji Su, Ju Liu, Changyong Cao, and Hongyan Yuan*. “A Minimally Designed Soft Crawling Robot for Robust Locomotion in Unstructured Pipes.” Bioinspiration Biomimetics 17, no. 5 (July 2022): 056001.

[J36] Tiankai Zhao, Jinrui Cao, Xin Li, Mingyong Xia, Bing Xue, and Hongyan Yuan*. “A Network-Based Visco-Hyperelastic Constitutive Model for Optically Clear Adhesives.” Extreme Mechanics Letters 51 (February 2022): 101594.

[J35] Tiankai Zhao, Yubing Sun, Qionghua Zhu, Xin Li, Mehdi Baghaee, Yuenan Wang, and Hongyan Yuan*. “A Contraction-Reaction-Diffusion Model for Circular Pattern Formation in Embryogenesis.” Journal of the Mechanics and Physics of Solids 157 (December 2021): 104630.  

[J34] Xie, T., Kang, J., Pak, C., Yuan, H. & Sun, Y. Temporal Modulations of NODAL, BMP, and WNT Signals Guide the Spatial Patterning in Self-Organized Human Ectoderm Tissues. Matter (2020) doi:10.1016/j.matt.2020.04.012.

[J33] Chen, S., Pang, Y., Yuan, H., Tan, X., Cao, C., 2020. Smart Soft Actuators and Grippers Enabled by Self-Powered Tribo-Skins. Advanced Materials Technologies.

[J32] Chen, S., Cao, Y., Sarparast, M., Yuan, H., Dong, L., Tan, X., Cao, C., 2019. Soft Crawling Robots: Design, Actuation, and Locomotion. Advanced Materials Technologies.

[J31] Marzban, B., J. Kang, N. Li, Y. Sun and Hongyan Yuan * (2019). "A contraction–reaction–diffusion model: Integrating biomechanics and biochemistry in cell migration." Extreme Mechanics Letters 32: 100566.  

Prior to SUSTech:

[J30] Kfoury, R., Marzban, B., Makki, E., Greenfield, M.L., Hongyan Yuan * , Effect of pressure profile of shock waves on lipid membrane deformation. PLoS ONE 14. (2019).

[J29] Wu, Z., Yuan, H., Zhang, X., Yi, X., Sidewall contact regulating the nanorod packing inside vesicles with relative volumes. Soft Matter 15, 2552–2559. (2019).

[J28] B. Marzban, X. Yi, Hongyan Yuan*, “A minimal mechanics model for mechanosensing of substrate rigidity gradient in durotaxis”, Biomechanics and Modeling in Mechanobiology, (Accepted: 6 January 2018). (* Corresponding author)

[J27] J. U. Lind, M. Yadid, I. Perkins, B. B. O’Connor, F. Eweje, C. O. Chantre, M. A. Hemphill, H. Yuan, P. Campbell, J. Vlassak, and K. K. Parker*, “Cardiac Microphysiological Devices with Flexible Thin Film Sensors for Higher-Throughput Drug Screening”, Lab on a chip, volume 17, issue 21, 2017.

[J26] Hongyan Yuan*, B. Marzban, and K. K. Parker*, “Myofibrils in Cardiomyocytes Tend to Assemble Along the Maximal Principle Stress Directions” Journal of Biomechanical Engineering, 139 (12), 2017.   

[J25] B. Marzban, and Hongyan Yuan*. “The Effect of Thermal Fluctuation on the Receptor-Mediated Adhesion of a Cell Membrane to an Elastic Substrate.” Membranes, volume 7, 2017. [CiteScore: 2.19] (* Corresponding author)

[J24] L. F. Deravi, N. R. Sinatra, C. O. Chantre, A. P. Nesmith, H. Yuan, S. K. Deravi, J. A. Goss, L. A. MacQueen, M. R. Badrossamy, G. M. Gonzalez, M. D. Phillips, and K. K. Parker*, “Design and Fabrication of Fibrous Nanomaterials Using Pull Spinning.” Macromolecular Materials and Engineering 302, no. 3 (2017).

[J23] [S.-P. Fu, Z. Peng, R. Kfoury, H. Yuan, and Y.-N. Young, “Lennard-Jones type pair-potential method for coarse-grained lipid bilayer membrane simulations in LAMMPS.” Computer Physics Communications, Volume 210, January 2017, Pages 193–203.] (https://www.sciencedirect.com/science/article/pii/S0010465516302892)   

[J22] J. U. Lind, T. A. Busbee, A. D. Valentine, F. S. Pasqualini, H. Yuan, M. Yadid, S. Park, A. Kotikian, A. P. Nesmith, P. H. Campbell, J. J. Vlassak, J. A. Lewis*, and K. K. Parker*, “Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing.” Nature Materials 16, 303–308 (2017).

[J21] B. Marzban and Hongyan Yuan*, “The effect of viscous force on the prediction of muscle contractility in biohybrid cantilever-based experiments,” Extrem. Mech. Lett., vol. 9, pp. 342–346, (2016). (* Corresponding author)

[J20] S.-J. Park, M. Gazzola, K. S. Park, S. Park, V. Di Santo, E. L. Blevins, J. U. Lind, P. H. Campbell, S. Dauth, A. K. Capulli, F. S. Pasqualini, S. Ahn, A. Cho, H. Yuan, B. M. Maoz, R. Vijaykumar, J.-W. Choi, K. Deisseroth, G. V. Lauder, L. Mahadevan, and K. K. Parker*, “Phototactic guidance of a tissue-engineered soft-robotic ray,” Science, vol. 353, no. 6295, pp. 158–162, (2016).

[J19] Y. Aratyn-Schaus, F. S. Pasqualini, H. Yuan, M. L. McCain, G. J. C. Ye, S. P. Sheehy, P. H. Campbell, and K. K. Parker, “Coupling primary and stem cell–derived cardiomyocytes in an in vitro model of cardiac cell therapy,” Journal of Cell Biology, Vol. 212 No. 4 389–397, (2016).

[J18] Holly McIlwee Golecki†, H. Yuan†, Benjamin Potter, Calla Glavin, Josue A. Goss, Michael D. Phillips, Kevin Kit Parker, Effect of Solvent Evaporation on Fiber Morphology in Rotary Jet-Spinning.” Langmuir, Oct. (2014) († Co-first author).

[J17] Gang Wang, Megan L McCain, Luhan Yang, Aibin He, Francesco Silvio Pasqualini, Ashutosh Agarwal, Hongyan Yuan, Dawei Jiang, Donghui Zhang, Lior Zangi, Judith Geva, Amy E Roberts, Qing Ma, Jian Ding, Jinghai Chen, Da-Zhi Wang, Kai Li, Jiwu Wang, Ronald JA Wanders, Wim Kulik, Frédéric M Vaz, Michael A Laflamme, Charles E Murry, Kenneth R Chien, Richard I Kelley, George M Church, Kevin Kit Parker, William T Pu, Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies, Nature Medicine, 20, 616–623 (2014)

[J16] Megan L. McCain†, H. Yuan†, Francesco S. Pasqualini, Patrick H. Campbell, and Kevin Kit Parker. Matrix elasticity regulates the optimal cardiac myocyte shape for contractility, American Journal of Physiology – Heart and Circulatory Physiology, 306: H1525–H1539, (2014). († Co-first author)

[J15] Yinfeng Li†, H. Yuan†, Annette Bussche†, Megan Creighton, Robert H. Hurt, Agnes B Kane, Huajian Gao, Graphene penetrates cell membranes spontaneously through edge asperities and corner sites, Proceedings of the National Academy of Sciences 110 (30), 12295-12300, (2013) († Co-first author)

[J14] Changjin Huang, Yao Zhang, Hongyan Yuan, Huajian Gao, and Sulin Zhang. Role of Nanoparticle Geometry in Endocytosis: Laying Down to Stand Up, Nano Letters 13, no. 9: 4546-4550, (2013)

[J13] Hongyan Yuan, and Huajian Gao, On the mechanics of integrin clustering during cell-substrate adhesion. Acta Mechanica Solida Sinica 25 (5), 467-472, (2012)

[J12] Hongyan Yuan, Changjin Huang, and Sulin Zhang, Membrane-Mediated Inter-Domain Interactions. BioNanoScience: p. 1-6, (2011)

[J11] Changjin Huang, Hongyan Yuan and Sulin Zhang. Coupled vesicle morphogenesis and domain organization. Applied Physics Letters. 98(4): p. 043702, (2011)

[J10] Hongyan Yuan, Ju Li, Sulin Zhang and Gang Bao. Variable nanoparticle-cell adhesion strength regulates cellular uptake. Physical Review Letters, 105(13): 138101, (2010)

[J9] Hongyan Yuan, Changjin Huang and Sulin Zhang. Dynamic shape transformations of fluid vesicles. Soft Matter, 6: 4571-4579, (2010)

[J8] Hongyan Yuan, Changjin Huang, Ju Li, George Lykotrafitis and Sulin Zhang. A one-particle-thick, solvent-free, coarse-grained model for biological and biomimetic fluid membranes. Physical Review E, 82(1): 011905, (2010). In this work, we developed an effective and accurate computational model for cell membrane.

[J7] Hongyan Yuan and Sulin Zhang. Effects of particle size and ligand density on the kinetics of receptor-mediated endocytosis of nanoparticles. Applied Physics Letters, 96(3): 033704, (2010)

[J6] Hongyan Yuan, Changjin Huang and Sulin Zhang. Virus-Inspired Design Maps of Nanoparticle-Based Bioagents. PLoS ONE, 5: e13495, (2010)

[J5] Xu Huang, Hongyan Yuan, K. Jimmy Hsia and Sulin Zhang. Coordinated Buckling of Thick Multi-Walled Carbon Nanotubes Under Uniaxial Compression. Nano Research, 3(1): 32-42, (2010)

[J4] Xu Huang, Hongyan Yuan, Wentao Liang and Sulin Zhang. Mechanical properties and deformation morphologies of covalently bridged multi-walled carbon nanotubes: Multiscale modeling. Journal of the Mechanics and Physics of Solids, 58, 1847–1862, (2010)

[J3] Sachin S. Terdalkar, Shan Huang, Hongyan Yuan, Joseph J. Rencis, Ting Zhu and Sulin Zhang. Nanoscale fracture in graphene. Chemical Physics Letters, 494(4-6): 218-222, (2010)

[J2] Hongyan Yuan, Jonah H. Lee and James E. Guilkey. Stochastic reconstruction of the microstructure of equilibrium form snow and computation of effective elastic properties. Journal of Glaciology, 56(197): 12, (2010)

[J1] Pu Yang, Yinghua Liu, Y. Ohtake, Hongyan Yuan, Zhangzhi Chen, Limit analysis based on a modified elastic compensate method for nozzle-to-cylinder junctions, International Journal of Pressure Vessels and Piping, 82: 770-776, (2005)