个人介绍：

戴紫薇2010年本科毕业于北京大学数学科学学院，2016年在北京大学定量生物学中心获得博士学位，同年赴美国杜克大学从事博士后研究，2021年2月全职回国加入南方科技大学生物系，担任助理教授。戴紫薇博士致力于基于计算和系统生物学的交叉学科研究，通过多组学数据分析和代谢网络定量建模方法的整合，研究肿瘤中的营养代谢，特别是葡萄糖和氨基酸代谢的异常，以及代谢对表观遗传修饰和基因表达的调控机制。研究成果发表在Nature, Cell Metabolism, Nature Reviews Genetics, Nature Genetics, Nature Communications，Science Advances, Metabolic Engineering, JBC等国际顶尖杂志，多次被选为封面文章，总引用次数超过1200次，并得到The Atlantic等知名杂志报道。

研究领域：

课题组运用组学数据分析和生物网络计算建模方法，定量、系统地研究细胞、组织乃至机体水平上的营养代谢，以及代谢与表观遗传修饰、基因表达调控以及人类疾病之间的关系。主要研究方向包括：

1. 肿瘤代谢

2. 表观遗传的代谢调控

3. 营养与人类健康

4. 生物网络计算建模和组学数据分析方法开发

工作经历：

2021.2 – 至今 助理教授

南方科技大学生物系

2016.6 – 2020.12 博士后

杜克大学药理学与癌症生物学系

导师：Jason W Locasale

学习经历：

2010.9 – 2015.12 物理化学，博士

北京大学定量生物学中心

导师：来鲁华

2006.9 – 2010.6 计算数学，学士

北京大学数学科学学院

导师：李铁军

所获荣誉：

2018 杜克大学Robert J Fitzgerald Scholar Award

2014 研究生国家奖学金

2014 北京大学校长奖学金

代表文章：

1. Inah Hwang, Hiroki Uchida, Ziwei Dai, Fei Li, Teresa Sanchez, Jason W Locasale, Lewis C Cant- ley, Hongwu Zheng, Jihye Paik*. Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification. Nat Commun. 2021 Jan 28;12(1):640.

2. Ziwei Dai, Vijyendra Ramesh, Jason W Locasale*. The evolving metabolic landscape of chro- matin biology and epigenetics. Nat Rev Genet. 2020 Dec;21(12):737-753.

3. Shiyu Liu, Ziwei Dai, Daniel E Cooper, David G Kirsch, Jason W Locasale*. Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle. Cell Metab. 2020 Oct 6;32(4):619-628.e21.

4. Ziwei Dai*, Jason W Locasale*. Cooperative virus propagation underlies COVID-19 transmission dynamics. medRxiv [Preprint]. 2020 May 7:2020.05.05.20092361.

5. Lake-Ee Quek*, James R Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J Fazakerley, Richard Scalzo, Sarah D Elkington, Ziwei Dai, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Jason W Locasale, Tomoyoshi Soga, David E James*, Shinya Kuroda*. Dynamic 13C flux analysis captures the reorganisation of adipocyte glucose metabolism in response to insulin. iScience. 2020 Jan 21.

6. Kevin H Lin, Justine C Rutter, Abigail Xie, Bryann Pardieu, Emily T Winn, Reinaldo Dal Bello, Antoine Forget, Raphael Itzykson, Yeong-Ran Ahn, Ziwei Dai, Raiyan T Sobhan, Grace R Anderson, Katherine R Singleton, Amy E Decker, Peter S Winter, Jason W Locasale, Lorin Craw- ford, Alexandre Puissant, Kris C Wood. Using antagonistic pleiotropy to design a chemotherapy- induced evolutionary trap to target drug resistance in cancer. Nat Genet. 2020 Apr;52(4):408- 417.

7. Zhengtao Xiao*, Jason W Locasale, Ziwei Dai. Metabolism in the tumor microenvironment: insights from single-cell analysis. OncoImmunology. 2020 Jan 1.

8. Maria V Liberti*, Annamarie E Allen, Vijyendra Ramesh, Ziwei Dai, Katherine R Singleton, Zufeng Guo, Jun O Liu, Kris C Wood, Jason W Locasale. Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis. J Biol Chem. 2019 Nov 20.

9. Ziwei Dai, Shiyu Yang, Liyan Xu, Hongrong Hu, Kun Liao, Jianghuang Wang, Qian Wang, Shuaishi Gao, Bo Li*, Luhua Lai*. Identification of cancer-associated metabolic vulnerabilities by modeling multi-objective optimality in metabolism. Cell Commun Signal. 2019 Oct 10;17(1):124.

10. Sydney M Sanderson, Xia Gao, Ziwei Dai, Jason W Locasale*. Methionine Metabolism in Health and Cancer: A Nexus of Diet and Targeted Medicine. Nat Rev Cancer. 2019 Sep 12.

11. Xia Gao, Sydney M Sanderson#, Ziwei Dai#, Michael A Reid, Daniel E Cooper, Min Lu, John P Richie, Amy Ciccarella, Ana Calcagnotto, Peter G Mikhael, Samantha J Mentch, Juan Liu, Gene Ables, David G Kirsch, David S Hsu, Sailendra N Nichenametla, Jason W Locasale*. Methionine metabolism links diet and nutrition to the efficacy of cancer therapies. Nature. 2019 Aug;572(7769):397-401.

12. Sydney M Sanderson, Peter G Mikhael, Vijyendra Ramesh, Ziwei Dai, Jason W Locasale*. Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells. Sci Adv. 2019 Jun26;5(6):eaav7769.

13. Zhengtao Xiao, Ziwei Dai*, Jason W Locasale*. Metabolic landscape of the tumor microenvi- ronment at single cell resolution. Nat Commun. 2019 Aug 21;10(1):3763.

14. Ziwei Dai*, Jason W Locasale*. Thermodynamic constraints on the regulation of metabolic fluxes. J Biol Chem. 2018 Dec 21;293(51):19725-19739.

15. Michael A Reid, Annamarie E Allen, Shiyu Liu, Maria V Liberti, Pei Liu, Xiaojing Liu, Ziwei Dai, Xia Gao, Qian Wang, Ying Liu, Luhua Lai, Jason W Locasale*. Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism. Nat Commun. 2018 Dec 21;9(1):5442.

16. Ziwei Dai, Samantha J Mentch, Xia Gao, Sailendra N Nichenametla, Jason W Locasale*. Methionine metabolism influences the genomic architecture of H3K4me3 with the link to gene expression encoded in peak width. Nat Commun. 2018 May 16;9(1):1955.

17. Hu Meng, Ziwei Dai, Weilin Zhang, Ying Liu, Luhua Lai*. Molecular mechanism of 15-lipoxygenase allosteric activation and inhibition. Phys Chem Chem Phys. 2018 May 30;20(21):14785-14795.

18. Michael A Reid, Ziwei Dai, Jason W Locasale*. The impact of cellular metabolism on chromatin dynamics and epigenetics. Nat Cell Biol. 2017 Nov;19(11):1298-1306.

19. Maria V Liberti, Ziwei Dai, Suzanne E Wardell, Joshua A Baccile, Xiaojing Liu, Xia Gao, Robert Baldi, Mahya Mehrmohamadi, Marc O Johnson, Neel S Madhukar, Alexander A Shestov, Iok I Christine Chio, Olivier Elemento, Jeffrey C Rathmell, Frank C Schroeder, Donald P McDonnell, Jason W Locasale*. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metab. 2017 Oct 3;26(4):648-659.

20. Ziwei Dai, Jason W Locasale*. Understanding metabolism with flux analysis: From theory to application. Metab Eng. 2017 Sep;43(Pt B):94-102.

21. Ziwei Dai, Jason W Locasale*. Metabolic pattern formation in the tumor microenvironment. Mol Syst Biol. 2017 Feb 9;13(2):915.

22. Ziwei Dai, Alexander A Shestov, Luhua Lai, Jason W Locasale*. A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect. Biophys J. 2016 Sep 6;111(5):1088- 100.

23. Hu Meng, Christopher L McClendon, Ziwei Dai, Kenan Li, Xiaoling Zhang, Shan He, Erchang Shang, Ying Liu, Luhua Lai*. Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution. J Med Chem. 2016 May 12;59(9):4202-9.

24. Youjun Xu, Ziwei Dai, Fangjin Chen, Shuaishi Gao, Jianfeng Pei, Luhua Lai*. Deep Learning for Drug-Induced Liver Injury. J Chem Inf Model. 2015 Oct 26;55(10):2085-93.

25. Yiran Wu, Xiaolong Zhuo, Ziwei Dai, Xiao Guo, Yao Wang, Chuanmao Zhang, Luhua Lai*. Modeling the mitotic regulatory network identifies highly efficient anti-cancer drug combinations. Mol Biosyst. 2015 Feb;11(2):497-505.

26. Ziwei Dai, Luhua Lai*. Differential simulated annealing: a robust and efficient global optimization algorithm for parameter estimation of biological networks. Mol Biosyst. 2014 Jun;10(6):1385- 92.

27. Cheng Zhu, Ziwei Dai, Huanhuan Liang, Tao Zhang, Feng Gai, Luhua Lai*. Slow and bimolecu- lar folding of a de novo designed monomeric protein DS119. Biophys J. 2013 Nov 5;105(9):2141-8.