新加坡国立大学分子生物学专业学士（2001）和计算机专业硕士（2005），并在加拿大多伦多大学获得博士（2011）学位，师从国际著名的细胞-细胞通讯和信号转导专家Tony Pawson院士。在博士攻读期间，致力于研究复杂生物系统和人类疾病的信号转导，并在该领域做出了重要的贡献（Tan et al. Science 2009; Tan et al. Science Signaling 2009, Tan et al. Nature Method 2012）。之后，在奥地利维也纳的分子医学中心（CeMM）参予发展了基于细胞热变换（CETSA）-质谱联用技术的药物靶标解析技术（Huber et al., Nature Method 2015）,开创了药物靶标解析方法的新领域。2015年，应CETSA技术发明人Pär Nordlund教授的邀请，加入了新加坡科技研究局分子与细胞生物学研究所(IMCB, A*STAR)，并发明了可以直接从完整细胞和组织中实时监测蛋白质复合物动态变化的系统技术，该工作于2018年发表于Science杂志 (Tan et al. Science 2018)。目前为止，他已经在国际期刊和会议上发表了30多篇文章，包括在Science, Nature Methods, Science Signaling 和 Bioinformatics 第一或通讯作者的文章，H-index为21。其工作受到了Science, Nature Genetics Review, Nature Methods, F1000Prime, Science Signaling, ACS Chemical Biology 和Cell Systems等杂志的高度评价。目前Tan教授担任Science, Nature Biotechnology, Nature Communication, 和Bioinformatics等高水平杂志的审稿人。

荣誉奖励：

2016年 新加坡科技研究局青年研究奖

2010年 多伦多大学最佳博士科研奖（Jennifer Dorrington奖）

1999年 新加坡国立大学理学院院长名单奖

近年资助:

2018.05-2021.04，新加坡Industry Alignment Fund，Toxicity Mode-of-Action Discovery (ToxMAD) Platform

2018.02-2019.01, 新加坡A*STAR-EDB Industry Alignment Fund，Study the Modes-of-Action (MoA) of Phthalates and Diketones using Toxicity MoA Discovery (ToxMAD) platform

2016.05- 2019.04, 新加坡A*STAR Young Investigator Award，Thermal Proximity-based Co-Aggregation for System-level Monitoring of Protein Complexes in Primary and Non-engineered Cells

代表性论文：

1. Z. Zheng, Y. Zeng, K. Lai,  B. Liao,  P. Li, &  C. S. H. Tan#(2023). Cellular protein painting for structural and binding sites analysis via lysine reactivity profiling with o-phthalaldehyde. bioRxiv, 2023-09.

2. Ji. H*, X. Lu*, S.Zhao, Q. Wang, B. Liao, L. G. Bauer, K. V. M. Huber, R. Luo, R. Tian and C. S. H. Tan# (2023). "Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions." Cell Chemical Biology.

3. Lu. X, B. Liao, S. Sun, Y. Mao, Q. Wu, R. Tian# and C. S. H. Tan#(2023). "Scaled-Down Thermal Profiling and Coaggregation Analysis of the Proteome for Drug Target and Protein Interaction Analysis." Analytical Chemistry.

4. Qiong. W, Jiangnan. Z, Xintong. S, Changying. F, Xiaozhen. C, Bin. L, Hongchao. J, Yang. L, An. H, Xue. L,  Chris Soon Heng. T# and Ruijun. T#(2023). "Fully automated and integrated proteomics sample preparation platform for high-throughput drug target identification." bioRxiv: 2023.2002.2013.528386.

5. Siyuan. S, Zhenxiang. Z, Jun. W, Fengming. L, An. H, Ruijun. T and Chris Soon Heng. T# (2023). "Improved in situ Characterization of Proteome-wide Protein Complex Dynamics with Thermal Proximity Co-Aggregation."  Nat Commun 14, 7697 (2023). https://doi.org/10.1038/s41467-023-43526-2

6. Y. Zhan, J. Liu, M. Wu, C. S. H. Tan, X. Li and L. Ou-Yang# (2023). "A partially shared joint clustering framework for detecting protein complexes from multiple state-specific signed interaction networks." Computers in Biology and Medicine 159: 106936.

7. Q. Zhu, J. Song, J.-Y. Chen, Z. Yuan, L. Liu, L.-M. Xie, Q. Liao, R. D. Ye, X. Chen, Y. Yan, J. Tan, C. S. Heng Tan, M. Li and J.-H. Lu# (2023). "Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease." Acta Pharmaceutica Sinica B 13(6): 2701-2714.

8. S. Zhang, Y. Dong, X. Chen, C.S.H Tan, M. Li, K. Miao, J. Lu# (2022) Toosendanin, a late-stage autophagy inhibitor, sensitizes triple-negative breast cancer to irinotecan chemotherapy Chinese Medicine, 17(1), 55.

9. H. Ji, X. Lu, Z. Zheng, S. Sun, C.S.H. Tan# (2022) ProSAP: a GUI software tool for statistical analysis and assessment of thermal stability data Briefings in Bioinformatics, 23(3). 

10. J. Zheng, A. He, Y. Mao, L. Yang, C.S.H. Tan, R. Tian# (2021) Proteomics in Precision Medicine Detection Methods in Precision Medicine, 58-72

11. Low. T. Y.*, Syafruddin. S. E., Mohtar. M. A, Vellaichamy. A, Rahman. N. S. A, Pung. Y.-F, &  C.S.H. Tan# (2021). Recent progress in mass spectrometry-based strategies for elucidating protein–protein interactions. Cellular and Molecular Life Sciences, 78(13), 5325–5339.

12. J. Zheng, X. Chen, Y. Yang, C.S.H. Tan & R. Tian# (2020) Mass Spectrometry-Based Protein Complex Profiling in Time and Space. Analytical Chemistry

13. Xavier. Bisteau, Joann. Lee, Vinayaka. Srinivas, Joanna. H. S. Lee, Joanna. Niska-Blakie, Gifford. Tan, Shannon. Y. X. Yap, Kevin. W. Hom, Cheng. Kit. Wong, Jeongjun. Chae, Loo. Chien. Wang, Jinho. Kim, Giulia. Rancati, Radoslaw. M. Sobota, C.S.H. Tan & Philipp Kaldis# (2020) The Greatwall Kinase Safeguards the Genome Integrity by Affecting the Kinome Activity in Mitosis. Oncogene, pp. 1–25.

14. Y.T. Lim, N. Prabhu, L. Dai, K.D. Go, D. Chen, L. Sreekumar, L. Egeblad, S. Eriksson, L. Chen, S. Veerappan, H.L. Teo, C.S.H. Tan, J. Lengqvist, A. Larsson, R.M. Sobota, P. Nordlund (2018). An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions. PLOS ONE 12 (12):e0208273.